|
Category:
|
7TM Receptors Peptides (Neuropeptides)Tachykinin ReceptorsNK-3 Receptor
|
|
Cat.No.
|
Product Name
|
|
1376 |
SB 218795
|
|
|
|
Price and Availability
Click here for full price details of
SB 218795
Other Information:
Sold
under license
|
|
Chemical Name:
(R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl
ester benzeneacetic acid |
|
|
Biological Activity:
Potent, selective and competitive non-peptide NK3
receptor antagonist (Ki = 13 nM at hNK3). Displays
90-fold and 7000-fold selectivity over hNK2 and hNK1
receptors respectively. Active in vivo, inhibiting agonist-induced pupillary
constriction.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Medhurst et al (1997) In vitro and in vivo
characterization of NK3 receptors in the rabbit eye by use of
selective non-peptide NK3 receptor antagonists. Br.J.Pharmacol. 122
469. Giardina et al (1997) Discovery of a novel class of
selective non-peptide antagonists for the human neurokinin-3 receptor. 1.
Identification of the 4-quinolinecarboxamide framework. J.Med.Chem. 40
1794.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: SB 218795, Peptides (Neuropeptides), Potent, Selective Non-peptide NK3 Antagonist, SB218795, Tocris Bioscience
|
|
Dedicated Customer Service
At Tocris we understand that customer service means more than just taking orders, we are here to act in partnership with you and to help you further your research. We do our best to ensure that your purchasing experience at Tocris is quick and effortless.
We are committed to making sure that over 99% of our products are in stock and in every case Tocris provides same day shipping of orders. Our friendly and efficient team delivers top quality support time after time.
|
|
