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Category: EnzymesarrowKinasesarrowGlycogen Synthase Kinase
Cat.No. Product Name
1616 SB 216763
Price and Availability

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SB 216763

Other Information:

Sold for research purposes under agreement from GlaxoSmithKline
Chemical Name: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-py rrole-2,5-dione

Biological Activity:

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Technical Data:

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M.Wt: 371.22
Formula: C19H12Cl2N2O2
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO
Purity: >99%
CAS No: [280744-09-4]

Resources:

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    References:

    Coghlan et al (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem.Biol. 7 793. Cross et al (2001) Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J.Neurochem. 77 94. Liang and Chuang (2006) Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J.Biol.Chem. 282 3904.
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    Keywords: SB 216763, Kinases, Potent Selective GSK-3 Inhibitor, SB216763, Tocris Bioscience
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