SB 216641 Hydrochloride | 5-HT Receptors | Selective H5-HT1B Antagonist | SB216641 Hydrochloride

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Cat.No.	Product Name
1242	SB 216641 hydrochloride

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SB 216641 hydrochloride

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Chemical Name: N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-meth yl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4 -carboxamide hydrochloride

Biological Activity:

A selective h5-HT_1B antagonist with approximately 25-fold selectivity over h5-HT_1D and little or no affinity for a range of other receptor types.

Technical Data:

M.Wt:	523.03
Formula:	C₂₈H₃₀N₄O₄.HCl
Storage:	Store at RT
Solubility:	Soluble to 50 mM in Water
Purity:	>98%
CAS No:	[170230-39-4]

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References:

Hagan et al (1997) Stimulation of 5-HT_1B receptors causes hypothermia in the guinea pig. Eur.J.Pharmacol. 331 169. Price et al (1997) SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT_1B and h5-HT_1D receptors. Naunyn-Schmied.Arch.Pharmacol. 356 312. Schlicker et al (1997) Effects of selective h5-HT_1B (SB-216641) and 5-HT_1D (BRL-15572) receptor ligands on guinea pig and human 5-HT auto- and heteroreceptors. Naunyn-Schmied.Arch.Pharmacol. 356 321.

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Keywords: SB 216641 Hydrochloride, 5-HT Receptors, Selective H5-HT1B Antagonist, SB216641 Hydrochloride, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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