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Category:
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Ion Channels Calcium ChannelsVoltage-gated Calcium Channels
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Cat.No.
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Product Name
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1439 |
Ruthenium Red
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Price and Availability
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Ruthenium Red
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Chemical Name:
Ammoniated ruthenium oxychloride |
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Biological Activity:
Blocks Ca2+ uptake and release from
mitochondria, and Ca2+ release from ryanodine-sensitive
intracellular stores. Also blocks cell membrane-located capsaicin-activated
cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels
to inhibit neurotransmitter release.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Bernardi et al
(1984) Pathway for uncoupler-induced calcium efflux in rat liver mitochondria:
inhibition by ruthenium red. Biochemistry 23 1645. Amann and
Maggi (1991) Ruthenium red as a capsaicin antagonist. Life Sci. 49
849. Szallasi and Blumberg (1999) Vanilloid (capsaicin) receptors and
mechanisms. Pharmacol.Rev. 51 159. Xu et al (1999)
Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release
channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 274
32680.
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View related products by Pharmacological Action
or by Research Area
Keywords: Ruthenium Red, Calcium Channels, Non-selective Ca2+ Channel Blocker (N- & P-type), Tocris Bioscience
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Literature in this Area Scientific Reviews
Mechanisms for Manipulating Intracellular Calcium Buffering Download PDF Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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