(R)-(-)-Rolipram | Phosphodiesterases | More Active Enantiomer Of Cat. No. 0905 | Rolipram

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Cat.No.	Product Name
1349	(R)-(-)-Rolipram

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(R)-(-)-Rolipram

Chemical Name: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2 -one

Biological Activity:

More active enantiomer of the PDE4 inhibitor rolipram (Cat. No. 0905); 2-10-fold more potent than the S-(+) enantiomer (Cat. No. 1350).

Technical Data:

M.Wt:	275.35
Formula:	C₁₆H₂₁NO₃
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[85416-75-7]

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Certificate of Analysis / MSDS:

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References:

Schneider et al (1986) Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 127 105. Owens et al (1997) Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 326 53. Ohsawa et al (1998) Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 77 147.

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Keywords: (R)-(-)-Rolipram, Phosphodiesterases, More Active Enantiomer Of Cat. No. 0905, Rolipram, Tocris Bioscience

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