Ro 60-0175 | 5-HT Receptors | Potent, Selective 5-HT2C Agonist | Ro60-0175

Category:

Cat.No.	Product Name
1854	Ro 60-0175 fumarate

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Ro 60-0175

Chemical Name: (aS)-6-Chloro-5-fluoro-a-methyl-1H-indole-1-ethanamine fumarate

Biological Activity:

Potent, selective 5-HT₂ receptor agonist; shows selectivity for the 5-HT_2C subtype (pK_i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT_2C, _2A, _1A, ₆ and ₇ receptors respectively). Centrally active following oral or systemic administration in vivo.

Technical Data:

M.Wt:	342.75
Formula:	C₁₁H₁₂ClFN₂.C₄H₄O₄
Storage:	Desiccate at RT
Solubility:	Soluble to 5 mM in Water
Purity:	>99%
CAS No:	[169675-09-6]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Martin et al (1998) 5-HT_2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 286 913. Kennett et al (2000) Effects of Ro 60 0175, a 5-HT_2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 387 197. Damjanoska et al (2003) Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine_2C receptor agonist. J.Pharmacol.Exp.Ther. 304 1209.

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Keywords: Ro 60-0175, 5-HT Receptors, Potent, Selective 5-HT2C Agonist, Ro60-0175, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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