Ro 20-1724 | Phosphodiesterases | PDE4 Inhibitor | Ro20-1724

Category:

Cat.No.	Product Name
0415	Ro 20-1724

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Ro 20-1724

Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone

Biological Activity:

Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC₅₀ = 2.0 μM).

Technical Data:

M.Wt:	278.35
Formula:	C₁₅H₂₂N₂O₃
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[29925-17-5]

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Certificate of Analysis / MSDS:

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References:

Reeves et al (1987) The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J. 241 535. Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19. Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci. 95 8991.

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Keywords: Ro 20-1724, Phosphodiesterases, PDE4 Inhibitor, Ro20-1724, Tocris Bioscience

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