Risperidone | 5-HT Receptors | 5-HT2A Antagonist | R 64 766

Category:

7TM Receptors

5-HT Receptors

5-HT2 Receptors

5-HT2A

Cat.No.

Product Name

2865

Risperidone

Alternative name(s):

R 64 766

Risperidone C23H27FN4O2 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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Risperidone

Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyri midin-4-one

Biological Activity:

Atypical antipsychotic agent that displays 5-HT_2A receptor antagonism. Also displays high affinity at D₂ receptors (K_i values are 0.4 and 3.13 nM for 5-HT_2A and D₂ receptors respectively).

Technical Data:

M.Wt:	410.48
Formula:	C₂₃H₂₇FN₄O₂
Storage:	Store at +4°C
Solubility:	Soluble to 10 mM in DMSO and to 10 mM in Ethanol
Purity:	>99%
CAS No:	[106266-06-2]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Leysen et al (1988) Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 247 661. Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 Suppl. 5. Stathis et al (1996) Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol. 127 181.

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Keywords: Risperidone, 5-HT Receptors, 5-HT2A Antagonist, R 64 766, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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