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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowMiscellaneous Glutamate
Cat.No. Product Name
0768 Riluzole hydrochloride  
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Riluzole hydrochloride
Chemical Name: 2-Amino-6-trifluoromethoxybenzothiazole hydrochloride

Biological Activity:

Novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischaemic and anaesthetic properties. Riluzole is able to act as a glutamate release inhibitor, blocks voltage-dependent Na+ channels and inhibits GABA uptake by striatal synaptosomes.

Technical Data:

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M.Wt: 270.66
Formula: C8H5F3N2OS.HCl
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 50 mM in Water
Purity: >99%
CAS No: [1744-22-5]

Resources:

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    References:

    Benazzouz et al (1995) Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study. Eur.J.Pharmacol. 284 299. Umeniya and Berger (1995) Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol. 116 3227. Taylor and Meldrum (1995) Na+ channels as targets for neuroprotective drugs. TiPS. 16 309. Song et al (1997) Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther. 282 707.

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    Keywords: Riluzole Hydrochloride, Ligand-gated Ion Channels, Glutamate Release Inhibitor / GABA Uptake Inhibitor, Tocris Bioscience
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