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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowIon Channel
Cat.No. Product Name
1622 Remacemide hydrochloride
Alternative name(s): FPL 12924AA
Price and Availability

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Remacemide

Other Information:

Sold with the permission of AstraZeneca UK Ltd
Chemical Name: 2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride

Biological Activity:

Uncompetitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC50 = 8-68 μM). Anticonvulsant in vivo and metabolises to a more potent desglycine analogue. Weakly blocks voltage-dependent Na+ channels (IC50 = 161 μM).

Technical Data:

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M.Wt: 304.82
Formula: C17H20N2O.HCl
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [111686-79-4]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Palmer et al (1995) Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann.N.Y.Acad.Sci. 765 236. Subramaniam et al (1996) Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J.Pharmacol.Exp.Ther. 276 161. Santangeli et al (2002) Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur.J.Pharmacol. 438 63.
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    Keywords: Remacemide, Ligand-gated Ion Channels, NMDA Antagonist; Blocks Ion Channel & Allosteric Modulatory Site, FPL 12924AA, Remacemide, Tocris Bioscience
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