Chemical Name:3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-
hydroxy-6-methoxybenzamide
Biological Activity:
Selective
and potent dopamine D2/D3 receptor antagonist (Ki
values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4
and D1 receptors respectively). Centrally active following systemic
administration in vivo.
Ogren et al (1986) The selective dopamine D2
receptor antagonist raclopride discriminates between dopamine-mediated motor
functions. Psychopharmacology 90 287. Hallet al
(1989) Animal pharmacology of raclopride, a selective dopamine D2
antagonist. Psychopharmacol.Ser. 7 123. Seeman and Van Tol
(1994) Dopamine receptor pharmacology. TiPS 15 264.
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