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Category:
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Enzyme-Linked Receptors Toll-like Receptors
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Cat.No.
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Product Name
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2719 |
RWJ 21757
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| Alternative name(s): |
Loxoribine |
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7-Allyl-8-oxoguanosine |
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Price and Availability
Click here for full price details of
RWJ 21757
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Chemical Name:
7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine |
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Biological Activity:
Toll-like receptor 7 (TLR7) agonist; induces
immune cell activation and increases cytokine production. Displays antitumour
and antiviral activity in various animal models.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Goodman et al
(1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the
cell cycle. Blood 84 3457. Lee et al (2003)
Molecular basis for the immunostimulatory activity of guanine nucleoside
analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100
6646. Heil et al (2003) The toll-like receptor 7 (TLR7)-specific
stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9
subfamily. Eur.J.Immunol. 33 2987.
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View related products by Pharmacological Action
or by Research Area
Keywords: RWJ 21757, Toll-like Receptors, Toll-like Receptor 7 (TLR7) Agonist, Loxoribine, 7-Allyl-8-oxoguanosine, RWJ21757, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
Purity To Rely On
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Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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