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Category:
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7TM Receptors Chemokine ReceptorsCCR
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Cat.No.
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Product Name
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2089 |
RS 102895 hydrochloride
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Price and Availability
Click here for full price details of
RS 102895
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Chemical Name:
1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-be
nzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride |
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Biological Activity:
CCR2-selective chemokine receptor antagonist (IC50
values are 0.36 and 17.8 μM for
inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks
MCP-1-stimulated calcium influx and chemotaxis with IC50 values of
32 nM and 1.7 μM
respectively. Also inhibits α1A, α1D
and 5-HT1A receptors.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Clark et al
(1983) Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones.
J.Med.Chem. 26 657. Mirzadegan et al (2000)
Identification of the binding site for a novel class of CCR2b chemokine
receptor antagonists. J.Biol.Chem. 275 25562.
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Keywords: RS 102895, Chemokine Receptors, CCR2b Chemokine Receptor Antagonist, RS102895, Tocris Bioscience
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