ROS 234 | Histamine Receptors | Potent H3 Antagonist | ROS234

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Cat.No.	Product Name
2034	ROS 234 dioxalate

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ROS 234

Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate

Biological Activity:

Potent H₃ antagonist (pK_B at guinea-pig ileum H₃-receptor = 9.46). Limited blood brain barrier permeability (ED₅₀ = 19.12 mg/kg i.p.).

Technical Data:

M.Wt:	421.37
Formula:	C₁₃H₁₅N₅.2C₂H₂O₄
Storage:	Desiccate at RT
Solubility:	Soluble to 50 mM in Water and to 50 mM in DMSO
Purity:	>99%
CAS No:	[184576-87-2]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Ballabeni et al (2002) CNS access of selected H₃-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 Suppl.1 S55. Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H₃-antagonists. Bioorg.Med.Chem.Lett. 12 663.

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Keywords: ROS 234, Histamine Receptors, Potent H3 Antagonist, ROS234, Tocris Bioscience

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