RJR 2403 fumarate

Alternative name(s):	Metanicotine
	TC-2403

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RJR 2403 fumarate

Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine fumarate

Biological Activity:

A neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (K_i values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.

Technical Data:

M.Wt:	278.31
Formula:	C₁₀H₁₄N₂.C₄H₄O₄
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in Water
CAS No:	[183288-99-5]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Bencherif et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J.Pharmacol.Exp.Ther. 279 1413. Lippiello et al (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J.Pharmacol.Exp.Ther. 279 1422. Damaj et al (1999) Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J.Pharmacol.Exp.Ther. 291 390.

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Keywords: RJR 2403 Fumarate, Ligand-gated Ion Channels, A4b2 Selective Nicotinic Agonist, Metanicotine, TC-2403, RJR2403 Fumarate, Tocris Bioscience

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