|
Category:
|
Enzymes EsterasesPhospholipase
|
|
Cat.No.
|
Product Name
|
|
1842 |
RHC 80267
|
| Alternative name(s): |
U 57908 |
|
|
Price and Availability
Click here for full price details of
RHC 80267
|
|
Chemical Name:
O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime
cyclohexanone |
|
|
Biological Activity:
Inhibitor of diacylglycerol lipase (IC50
values are 1.1 and 4 μM
in rat cardiac myocytes and canine platelets respectively). Weakly inhibits
phospholipases C and A2. Potentiates acetylcholine evoked relaxation
in mesenteric arteries by the inhibition of cholinesterase activity (IC50
= 4 μM).
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
|
|
|
References:
Sutherland and Amin (1982)
Relative activities of rat and dog platelet phospholipase A2 and
diglyceride lipase. J.Biol.Chem. 257 14006. Suzuki et
al (2002) Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on
excitation of circular smooth muscle of the guinea-pig gastric antrum. J.Smooth
Musc.Res. 38 153. Ghisdal et al (2005) The
diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to
acetylcholine in rat mesenteric artery by anti-cholinesterase action.
Eur.J.Pharmacol. 517 97.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: RHC 80267, Esterases, Diacylglycerol Lipase Inhibitor. Weak Inhibitor Of PLC & PLA2, U 57908, RHC80267, Tocris Bioscience
|
|
Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Products You Can Trust
When you buy a product from Tocris you know you are buying the genuine article.
If we supply a patented product we will always seek to obtain a licence from the patent holder and ensure that our product meets or exceeds specifications.
Our reputation for integrity and uncompromising quality allows us to partner with world-class scientific organisations to bring novel and exclusive products to market.
|
|
