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Chemical Name:(L)-(+)-a-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propan
oic acid
Biological Activity:
Glutamate receptor agonist acting at AMPA receptors and
metabotropic glutamate receptors positively linked to phosphoionositide
hydrolysis. Sensitises neurons in hippocampus to depolarization by L-AP6 (the so called
'quis' effect).
Porteret al (1992) (S)-Homoquisqualate: a potent agonist at the
glutamate metabotropic receptor. Br.J.Pharmacol. 106 509. Schulteet al (1994) Utilization of the resolved L-isomer of
2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a
quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649
203. Littmanet al (1995) Effects of quisqualic acid analogs on
metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat
hippocampus. Neuropharmacology 34 829.
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