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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowNMDA SitearrowAgonists
Cat.No. Product Name
0225

Quinolinic acid  

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Quinolinic acid
Chemical Name: Pyridine-2,3-dicarboxylic acid

Biological Activity:

Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.

Technical Data:

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M.Wt: 167.12
Formula: C7H5NO4
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH
CAS No: [89-00-9]

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    References:

    Stone and Perkins (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in the rat CNS. Eur.J.Pharmacol. 72 411. Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Progr.Neurobiol. 30 333. Monaghan and Beaton (1991) Quinolinate differentiates between forebrain and cerebellar NMDA receptors. Eur.J.Pharmacol. 194 123. Prada de Carvalho et al (1996) The endogenous agonist quinolinic acid and the non-endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem.Int. 28 445,

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    Keywords: Quinolinic Acid, Ligand-gated Ion Channels, Transmitter Candidate, Tocris Bioscience
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