Chemical Name:N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium
bromide
Biological Activity:
Membrane impermeable quaternary
derivative of lidocaine, a blocker of voltage-activated Na+
channels. Intracellular QX 314 bromide also inhibits calcium currents in
hippocampal CA1 pyramidal neurons.
Stichartz et al (1973) The inhibition of sodium
currents in myelinated nerve by quaternary derivatives of lidocaine.
J.Gen.Physiol. Alreja and Aghajanian (1994) QX-314 blocks the potassium
but not the sodium dependent components of the opiate response in locus
coeruleus neurons. Brain Res. 639 320. Perkins and Wong
(1995) Intracellular QX-314 blocks the hyperpolarization activated inward
current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72
911. Talbot and Sayer (1996) Intracellular QX-314 inhibits calcium
currents in hippocampal CA1 pyramidal neurons. J.Neurophysiol. 76
2120.
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