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Category:
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Cellular Processes and Components Signal TransductionCytokine and NFkB SignallingNFkB/IkB
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Cat.No.
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Product Name
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0727 |
Pyrrolidinedithiocarbamate ammonium
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Price and Availability
Click here for full price details of
Pyrrolidinedithiocarbamate ammonium
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Biological Activity:
This inhibitor of nuclear factor κB
(NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without
affecting the formation of NO-synthase mRNA produced by cAMP.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Eberhardt et al (1994) Pyrrolidine dithiocarbamate
differentially affects 1β - and cAMP-induced NO-synthase expression in rat
renal mesangial cells. Biochem.Biophys.Res.Comm. 200 163. Schini-Kerth
(1994) Pyrrolidine dithiocarbamate selectively prevents the expression of
the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265
83. Bessho et al (1994) Pyrrolidine dithiocarbamate, a
potent inhibitor of nuclear factor κ B (NF-κ B)
activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and
thymocytes. Biochem.Pharmacol. 48 1883.
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Keywords: Pyrrolidinedithiocarbamate Ammonium, Signal Transduction, Inhibits NF-kB, Prevents Increase In NOS MRNA, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Proteasome and NF-κB
Key proteasome inhibitors now available from Tocris include:
1748
MG 132
Proteasome & calpain inhibitor. Inhibits NF-κB activation
2637
Gliotoxin
Immunosuppressant; inhibits NF-κB & cytokine production
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