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Piribedil hydrochloride
Chemical Name:2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimid
ine dihydrochloride
Biological Activity:
A direct dopamine agonist, in clinical use for treatment of
dopaminergic system dysfunction. Recent work suggests that it is selective for
the D3 subtype, for which it has 20 times higher affinity than for D2,
and possesses no significant affinity for D1receptors.
Merck
Index 12 7648. Offermeier and van Rooyen (1986) A
comparative study of the locomotor activity effects of apomorphine and the
'atypical dopamine agonists' (piribedil and S36080). Life Sci. 38
895. Jenner (1992) Parkinson's disease: pathological mechanisms and
actions of piribedil. J.Neurol. 239 S2. Cagnottoet al
(1996) In vitro affinity of piribedil for dopamine D3 receptor
subtypes, an autoradiographic study. Eur.J.Pharmacol. 313 63.
