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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA SelectivearrowAntagonists
Cat.No. Product Name
2770 Philanthotoxin 74
Alternative name(s): PhTx-74
Price and Availability

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Philanthotoxin 74
Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-a-[(1-o xobutyl)amino]benzenepropanamide dihydrochloride

Biological Activity:

Subtype-selective AMPA receptor antagonist; inhibits GluR1/2 but not GluR2/3 receptors.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 507.54
Formula: C24H42N4O3.2HCl
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water and to 100 mM in DMSO
Purity: >98%
CAS No: [401601-12-5]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc.129 4902.
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    Keywords: Philanthotoxin 74, Ligand-gated Ion Channels, GluR1 / 2 Selective AMPA Antagonist, PhTx-74, Tocris Bioscience
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