Phaclofen | GABAB Receptors | Weak, Selective GABAB Antagonist

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7TM Receptors

GABAB Receptors

Antagonists

Cat.No.	Product Name
0178	Phaclofen

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Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid

Biological Activity:

Selective GABA_B antagonist. Phosphono analogue of GABA_B agonist baclofen (Cat. No. 0417).

Technical Data:

M.Wt:	249.63
Formula:	C₉H₁₃CINO₃P
Solubility:	Soluble to 100 mM in 1eq. NaOH
Storage:	Store at RT
CAS No:	[114012-12-3]

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References:

Kerr et al (1987) Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 405 150. Karlsson et al (1988) Phaclofen: a GABA_B blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485. Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of baclofen induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77.

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Keywords: Phaclofen, GABAB Receptors, Weak, Selective GABAB Antagonist, Tocris Bioscience

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Scientific Reviews

GABA Receptors
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