Peptide YY (3-36) | Peptides (Neuropeptides) | Selective Y2 Receptor Agonist

Category:

Cat.No.	Product Name
1618	Peptide YY (3-36)

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Peptide YY (3-36)

Biological Activity:

Y₂ selective agonist. IC₅₀ values are 0.11 and 1050 nM for inhibition of ¹²⁵I-PYY binding to Y₂ and Y₁ receptors respectively. Inhibits food intake and reduces weight gain in vivo. Brain penetrant.

Technical Data:

M.Wt:	3980.4
Formula:	C₁₇₆H₂₇₂N₅₂O₅₄
Storage:	Desiccate at -20°C
CAS No:	[126339-09-1]

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References:

Keire et al (2000) Primary structures of PYY, [Pro³⁴]PYY and PYY-(3-36) confer different conformations and receptor selectivity. Am.J.Physiol.Gastrointest.Liver Physiol. 279 G126. Batterham et al (2002) Gut hormone PYY_3-36 physiologically inhibits food intake. Nature 418 650. Nonaka et al (2003) Characterization of blood-brain barrier permeability to PYY_3-36 in the mouse. J.Pharmacol.Exp.Ther. 306 948.

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Keywords: Peptide YY (3-36), Peptides (Neuropeptides), Selective Y2 Receptor Agonist, Tocris Bioscience

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