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Category:
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Ion Channels Potassium ChannelsCa2+-Activated Potassium Channels
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Cat.No.
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Product Name
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2006 |
Paxilline
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Price and Availability
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Paxilline
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Chemical Name:
(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,1
4a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b
,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]in
deno[1,2-b]indol-3(4bH)-one |
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Biological Activity:
Potent blocker of high-conductance Ca2+-activated K+
(BKCa) channels. Binds to the α-subunit of BKCa (Ki = 1.9 nM for
block of currents in α-subunit-expressing
oocytes) and enhances binding of charybdotoxin to BKCa channels in
vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase
(IC50 = 5-50 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Knaus et al (1994) Tremorgenic indole alkaloids potently inhibit smooth
muscle high-conductance calcium-activated potassium channels. Biochemistry 33
5819. Sanchez and McManus (1996) Paxilline inhibition of the
alpha-subunit of the high-conductance calcium-activated potassium channel.
Neuropharmacology 35 963. Bilmen et al (2002) The
mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+
ATPase by paxilline. Arch.Biochem.Biophys. 406 55.
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or by Research Area
Keywords: Paxilline, Potassium Channels, Potent Blocker Of BKCa Channels, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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