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Category:
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7TM Receptors Adenosine ReceptorsAntagonists
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Cat.No.
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Product Name
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2019 |
PSB 36
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Price and Availability
Click here for full price details of
PSB 36
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Chemical Name:
1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7
-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione |
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Biological Activity:
Potent
and selective A1 adenosine receptor antagonist. Displays binding
affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B,
rA2A, rA3 and hA3 receptors respectively.
Demonstrates greater selectivity than DPCPX (Cat. No. 0439).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Abo-Salem et al (2004) Antinociceptive effects of
novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 308
358. Weyler et al (2006) Improving potency, selectivity, and
water solubility of adenosine A1 receptor antagonists: xanthines modified at
position 3 and related pyrimido[1,2,3-cd]purinediones. Chemmedchem 1
891.
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or by Research Area
Keywords: PSB 36, Adenosine Receptors, Potent, A1-selective Antagonist, PSB36, Tocris Bioscience
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