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Category:
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Cellular Processes and Components Cell Cyclep53
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Cat.No.
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Product Name
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1862 |
PRIMA-1
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Price and Availability
Click here for full price details of
PRIMA-1
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Chemical Name:
2,2-Bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
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Biological Activity:
Selectively restores mutant p53 activity in
tumour cells via activation of Bax and PUMA. Induces apoptosis and inhibits
growth of human tumours with mutant p53.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Bykov et al
(2002) Restoration of the tumour suppressor function to mutant p53 by a
low-molecular-weight compound. Nature Med. 8 282. Bykov et
al (2002) Mutant p53-dependent growth suppression distinguishes PRIMA-1
from known anticancer drugs: a statistical analysis of information in the
National Cancer Institute database. Carcinogenesis 23 2011. Wang
et al (2007) PRIMA-1 induces apoptosis by inhibiting JNK signalling but
promoting the activation of Bax. Biochem.Biophys.Res.Comm. 352
203.
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View related products by Pharmacological Action
or by Research Area
Keywords: PRIMA-1, Cell Cycle, Restores Mutant P53 Activity; Induces Apoptosis, Tocris Bioscience
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