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Category:
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Other Activities Sigma and ImidazolineSigma LigandsSigma1
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Cat.No.
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Product Name
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0589 |
PRE-084 hydrochloride
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Price and Availability
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PRE-084 hydrochloride
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Chemical Name:
2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate
hydrochloride |
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Biological Activity:
High affinity, selective σ 1
agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors
respectively). Selective over PCP receptors (IC50 > 100000 nM)
and several other receptor systems. Produces antiamnesic and antitussive
effects in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Su et al (1992) Sigma compounds derived from phencyclidine.
Identification of PRE-084, a new selective sigma ligand. J.Pharmacol.Exp.Ther. 259
543. Maurice et al (1999) The attenuation of learning impairments
induced after exposure to CO or trimethyltin in mice by sigma (σ)
receptor ligands involves both σ1 and σ2 sites. Br.J.Pharmacol. 127 335. Brown et
al (2004) Antitussive activity of sigma-1 receptor agonists in the
guinea-pig. Br.J.Pharmacol. 141 233.
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or by Research Area
Keywords: PRE-084 Hydrochloride, Sigma & Imidazoline, Highly Selective S1 Agonist, PRE084 Hydrochloride, Tocris Bioscience
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