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Category:
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Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs)Insulin and insulin-like
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Cat.No.
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Product Name
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2768 |
PQ 401
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Price and Availability
Click here for full price details of
PQ 401
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Chemical Name:
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)
urea |
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Biological Activity:
Insulin-like growth factor receptor (IGF-IR)
inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50
value of 12 μM.
Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Anderson et al
(2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of
insulin-like growth factor receptor. J.Comb.Chem. 8 784. Gable
et al (2006) Diarylureas are small-molecule inhibitors of insulin-like
growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer. 5
1079.
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View related products by Pharmacological Action
or by Research Area
Keywords: PQ 401, Receptor Tyrosine Kinases (RTKs), IGF-IR Inhibitor, PQ401, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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