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Category: EnzymesarrowKinasesarrowSrc Family Kinases
Cat.No. Product Name
1407 PP 2
Price and Availability

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PP 2
Chemical Name: 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ami ne

Biological Activity:

Selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and Jak2. Moderately inhibits CSK (IC50 = 0.73 μM).

Technical Data:

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M.Wt: 301.78
Formula: C15H16ClN5
Storage: Desiccate at +4°C
Solubility: Soluble to 25 mM in DMSO and to 10 mM in Ethanol
Purity: >99%
CAS No: [172889-27-9]

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    References:

    Hanke et al (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. J.Biol.Chem. 271 695. Lawrence and Niu (1998) Protein kinase inhibitors: the tyrosine-specific protein kinases. Pharmacol.Ther. 77 81. Sanna et al (2000) A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proc.Natl.Acad.Sci.USA 97 8653. Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199.
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    Keywords: PP 2, Kinases, Potent, Selective Src Inhibitor, PP2, Tocris Bioscience
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