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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowP2X ReceptorsarrowAntagonists
Cat.No. Product Name
1309 PPNDS
Price and Availability

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PPNDS
Chemical Name: Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8' -disulfonate) tetrasodium salt

Biological Activity:

Potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.

Technical Data:

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M.Wt: 694.36
Formula: C18H11N4Na4O14PS2
Storage: Desiccate at -20°C
Solubility: Soluble to 100 mM in Water

Resources:

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Lambrecht et al (2000) The novel pyridoxal-5´-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur.J.Pharmacol. 387 R19.
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    Keywords: PPNDS, Ligand-gated Ion Channels, Potent, Selective P2X1 Antagonist, Tocris Bioscience
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