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Category: 7TM ReceptorsarrowGlutamate (Metabotropic) ReceptorsarrowGroup III mGlu ReceptorsarrowAgonists
Cat.No. Product Name
1220 (RS)-PPG
Price and Availability

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(RS)-PPG
Chemical Name: (RS)-4-Phosphonophenylglycine

Biological Activity:

A potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8; anticonvulsant and neuroprotective in vivo.

Technical Data:

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M.Wt: 231.14
Formula: C8H10NO5P
Storage: Store at RT
Solubility: Soluble to 100 mM in 1eq. NaOH
CAS No: [120667-15-4]

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    References:

    Bigge et al (1989) Exploration of phenyl-spaced 2-amino-(5,9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists. J.Med.Chem. 32 1580. Flor et al (1998) Neuroprotection in vitro and in vivo by (R,S)-PPG, a potent and selective group III metabotropic glutamate receptor agonist. Soc.Neurosci.Abstr. 24 431.11. Gasparini et al (1999) (R,S)-4-Phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J.Pharmacol.Exp.Ther. 290 1678.
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    Keywords: (RS)-PPG, Glutamate (Metabotropic) Receptors, Potent, Selective MGlu8 Agonist, PPG, Tocris Bioscience

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