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Category:
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Ion Channels Potassium ChannelsATP-Activated Potassium Channels
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Cat.No.
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Product Name
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2095 |
PNU 37883 hydrochloride
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Price and Availability
Click here for full price details of
PNU 37883 hydrochloride
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Chemical Name:
N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholi
necarboximidamide hydrochloride |
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Biological Activity:
Novel antagonist selective for the vascular form of KATP
channel; inhibits KATP currents in isolated mesenteric artery smooth
muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes.
In vivo, inhibits blood vessel relaxation and hypotension induced by pinacidil.
Displays weak diuretic effects.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Humphrey
and Ludens (1998) KATP-blocking
diuretic PNU-37883A reduces plasma renin activity in dogs.
J.Cardiovasc.Pharmacol. 31 894. Cui et al (2003)
Different molecular sites of action for the KATP channel inhibitors,
PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122. Kovalev
et al (2004) Molecular analysis of the subtype-selective inhibition of
cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141
867.
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or by Research Area
Keywords: PNU 37883 Hydrochloride, Potassium Channels, Vascular KATP Channel Blocker, PNU37883 Hydrochloride, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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