PNU 109291 | 5-HT Receptors | Potent & Selective 5-HT1D Agonist | PNU109291

Category:

Cat.No.	Product Name
2556	PNU 109291

Price and Availability

Click here for full price details of
PNU 109291

Chemical Name: (S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl ]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide

Biological Activity:

Potent and selective 5-HT_1D receptor agonist that displays > 600-fold selectivity over 5-HT_1A and 5-HT_2A receptors and no activity at 5-HT_1B, 5-HT_1E, 5-HT_2B, 5-HT_2C, 5-HT₆ and 5-HT₇ receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

Technical Data:

M.Wt:	409.52
Formula:	_C24H31N3O3
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[187665-60-7]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Ennis et al (1998) Isochroman-6-carboxamides as highly selective 5-HT_1D agonists: potential new treatment for migraine without cardiovascular side effects. J.Med.Chem. 41 2180. Bhattacharya et al (2004) 5-Hydroxytryptamine_1B receptor-mediated contraction of rabbit saphenous vein and basilar artery: role of vascular endothelium. J.Pharmacol.Exp.Ther. 309 825. Cutrer et al (1999) Effects of PNU-109,291, a selective 5-HT_1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacol. 38 1043.

View related products by Pharmacological Action or by Research Area

Keywords: PNU 109291, 5-HT Receptors, Potent & Selective 5-HT1D Agonist, PNU109291, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
Download PDF

Featured New Product

Selective 5-HT₇ antagonist

2726 SB 258719

Selective 5-HT₇ receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.

View all Featured New Products

New Products in this Area

	2556	PNU 109291
	Potent and selective 5-HT_1D agonist
	3041	CP 809101 hydrochloride
	Potent and selective 5-HT_2C agonist
	3085	Ziprasidone hydrochloride
	5-HT_2A/D₂ antagonist; atypical antipsychotic
	1985	PNU 142633
	Highly selective 5-HT_1D agonist
	2643	DOI hydrochloride
	Mixed 5-HT_2A/2C agonist
	2901	SB 242084
	Selective 5-HT_2C antagonist; brain penetrant
	2925	LP 12 hydrochloride
	5-HT₇ agonist
	2726	SB 258719 hydrochloride
	Selective 5-HT₇ antagonist
	2739	U 92016A
	Selective 5-HT_1A agonist
	2865	Risperidone
	5-HT_2A antagonist
	2746	Amperozide hydrochloride
	Atypical antipsychotic; high affinity 5-HT₂ ligand
	2844	Mosapride citrate
	5-HT₄ agonist and 5-HT₃ antagonist
	2777	Nefazodone hydrochloride
	5-HT_2A antagonist and 5-HT uptake inhibitor. Antidepressant
	2645	Fananserin
	5-HT_2A antagonist. Also D₄ antagonist
	2592	TCB-2
	Potent, high affinity 5-HT_2A agonist
	2495	Melperone hydrochloride
	5-HT_2A/D₂ receptor antagonist; neuroleptic
	2451	LY 344864 hydrochloride
	Potent, selective 5-HT_1F agonist
	2534	LP 44
	High affinity 5-HT₇ agonist

for new product e-alerts

User ID
Password