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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowBenzodiazepines
Cat.No. Product Name
0670 PK 11195  
Price and Availability

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PK 11195
Chemical Name: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoqui nolinecarboxamide

Biological Activity:

Possesses high affinity for the MDR (peripheral benzodiazepine receptor) without binding to other known neurotransmitter receptors.

Technical Data:

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M.Wt: 352.86
Formula: C21H21ClN2O
Storage: Store at RT
Solubility: Soluble to 75 mM in Ethanol and to 100 mM in DMSO
Purity: >98%
CAS No: [85532-75-8]

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    References:

    Le Fur et al (1983) Differentiation between two ligands for peripheral benzodiazpine binding sites [3H]-Ro 5-4864 and [3H]-PK11195, by thermodynamic studies. Life Sci. 33 449. Conway et al (1997) Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and α2-adrenoceptor binding in the hippocampus following transient global forebrain ischaemia in the rat. Neuroscience 82 805.

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    Keywords: PK 11195, Ligand-gated Ion Channels, Antagonist At Peripheral BDZ Receptors, PK11195, Tocris Bioscience
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