PIT | P2Y Receptors | P2Y Ligand; Displays Mixed Antagonism / Potentiation | 2,2-Pyridylisatogen Tosylate

Category:

7TM Receptors

P2Y Receptors

Other P2Y

Cat.No.

Product Name

1682

PIT

Alternative name(s):

2,2'-Pyridylisatogen tosylate

PIT C13H8N2O2.C7H8O3S 2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate

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PIT

Chemical Name: 2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate

Biological Activity:

Purinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y₁ receptor and sympathetic/purinergic nerve stimulation).

Technical Data:

M.Wt:	396.42
Formula:	C₁₃H₈N₂O_2.C₇H₈O₃S
Storage:	Desiccate at +4°C
Solubility:	Soluble to 15 mM in Ethanol and to 80 mM in DMSO
Purity:	>99%
CAS No:	[56583-49-4]

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References:

Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575. King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P_2Y1 purinoceptor. Br.J.Pharmacol. 117 1111. Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530.

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Keywords: PIT, P2Y Receptors, P2Y Ligand; Displays Mixed Antagonism / Potentiation, 2,2-Pyridylisatogen Tosylate, Tocris Bioscience

Literature in this Area

Scientific Reviews

Nucleotide & Nucleoside Receptors
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