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PD 168077 maleate
Chemical Name:N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamid
e maleate
Biological Activity:
A potent D4 dopamine
receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2
and > 300-fold selectivity
versus D3 subtypes
respectively. Induces synaptic translocation of CaMK II to postsynaptic sites
in cultured prefrontal cortical neurons. Centrally active in vivo.
Glaseet
al (1997) Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective
dopamine D4 agonists. J.Med.Chem. 40 1771. Clifford
and Waddington (2000) Topographically based search for an
"Ethogram" among a series of novel D4 dopamine receptor
agonists and antagonists. Neuropsychopharmacology 22 538. Guet al (2006) Activation of dopamine D4 receptors induces
synaptic translocation of Ca2+/calmodulin-dependent protein kinase
II in cultured prefrontal cortical neurons. Mol.Pharmacol. 69
813.
