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Category: 7TM ReceptorsarrowPeptides (Cardiovascular)arrowAngiotensin Receptors
Cat.No. Product Name
1361 PD 123319 ditrifluoroacetate
Price and Availability

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PD 123319
Chemical Name: 1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(dipheny lacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6 -carboxylic acid ditrifluoroacetate

Biological Activity:

Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

Technical Data:

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M.Wt: 736.67
Formula: C31H32N4O3.2CF3CO2H
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [130663-39-7]

Resources:

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    References:

    Blankley et al (1991) Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J.Med.Chem. 34 3248. Boulay et al (1992) Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol.Pharmacol. 41 809. Tamura et al (2000) Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J.Hypertens. 18 1239.
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    Keywords: PD 123319, Peptides (Cardiovascular), Potent, Selective Non-peptide AT2 Antagonist, PD123319, Tocris Bioscience

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