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Category: 7TM ReceptorsarrowAcetylcholine (Muscarinic) ReceptorsarrowAntagonists
Cat.No. Product Name
1671 PD 102807
Price and Availability

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PD 102807
Chemical Name: 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino [1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester

Biological Activity:

Selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively.

Technical Data:

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M.Wt: 392.45
Formula: C23H24N2O4
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO
Purity: >98%
CAS No: [23062-91-1]

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    References:

    Augelli-Szafran et al (1998) Identification and characterization of m4 selective muscarinic antagonists. Bioorg.Med.Chem.Lett. 8 1991. Kitaichi et al (1999) A novel muscarinic M4 receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M2 receptor sub-type. Eur.J.Pharmacol. 383 53. Bohme et al (2002) Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors. J.Med.Chem. 45 3094.
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    Keywords: PD 102807, Acetylcholine (Muscarinic) Receptors, Selective M4 Antagonist, PD102807, Tocris Bioscience
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