Tocris Bioscience
Welcome to Tocris

Category: TransportersarrowNeurotransmitter TransportersarrowGlutamate Transporters
Cat.No. Product Name
0298

L-trans-2,4-PDC  

Alternative name(s): trans-4-Carboxy-L-proline
Price and Availability

Click here for full price details of
L-trans-2,4-PDC
Chemical Name: L-trans-Pyrrolidine-2,4-dicarboxylic acid

Biological Activity:

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.

Technical Data:

Click here for more information on batch specific data
M.Wt: 159.14
Formula: C6H9NO4
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >97%
CAS No: [64769-66-0]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    For specific/earlier batch please select:  
    Product/Material Safety Data Sheet: View current batch
    For specific/earlier batch please select:  

    References:

    Bridges et al (1991) Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J.Med.Chem. 34 717. Mitrovic and Johnston (1994) Regional differences in the inhibition of L-glutamate amd L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylic threo-3-hydroxy-D-aspartate and D-aspartate. Neurochem.Int. 24 583. Zuiderwijk et al (1996) Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus. Eur.J.Pharmacol. 307 275.
    View related products by Pharmacological Action or by Research Area

    Keywords: L-trans-2,4-PDC, Neurotransmitter Transporters, Transportable EAAT1-4 Inhibitor / Non-transportable EAAT5 Inhibitor, trans-4-Carboxy-L-proline, L2,4-PDC, Tocris Bioscience

    New Product Guide
    Tocris Bioscience. Our latest New Product Guide highlights over 140 new productsOur latest New Product Guide highlights over 140 new products.
    Request Copy / View PDF
    Dedicated Customer Service
    At Tocris we understand that customer service means more than just taking orders, we are here to act in partnership with you and to help you further your research. We do our best to ensure that your purchasing experience at Tocris is quick and effortless.

    We are committed to making sure that over 99% of our products are in stock and in every case Tocris provides same day shipping of orders. Our friendly and efficient team delivers top quality support time after time.
    New Products in this Area

     2789NFPS
     Selective non-transportable GlyT1 inhibitor
     3067Desipramine hydrochloride
     Selective inhibitor of noradrenalin transporters
     2833Cocaine hydrochloride
     Inhibitor of monoamine transporters
     2532TFB-TBOA
     High affinity EAAT1 and EAAT2 blocker
     2975Sarcosine
     GlyT1 inhibitor
     2924NBMPR
     Equilibrative nucleoside transporter 1 (ENT1) inhibitor
     2831Bupropion hydrochloride
     Non-selective inhibitor of dopamine and noradrenalin transporters
     2917Venlafaxine hydrochloride
     Dual serotonin/noradrenaline reuptake inhibitor
     2747NNC 05-2090 hydrochloride
     GABA uptake inhibitor; moderately BGT-1 selective
     2742Reserpine
     Inhibitor of vesicular monoamine transport
    Sign-up for new product e-alerts
    Log In / Register

    User ID
    Password
    If you are not registered with us Create Account