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Orexin A (human, rat, mouse)
Biological Activity:
Endogenous agonist at orexin receptors (Ki
values are 20 and 38 nM for OX1 and OX2 receptors
respectively). Stimulates feeding following central administration and may be
involved in the control of sleep-wake cycle and other hypothalamic functions.
Sakuraiet al
(1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and
G protein-coupled receptors that regulate feeding behaviour. Cell 92
573. Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83
695. Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor
system: implications for sleep and sleep disorders. TiNS 23 359.
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