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Category: EnzymesarrowKinasesarrowCyclin-dependent Kinase
Cat.No. Product Name
1284 Olomoucine  
Price and Availability

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Olomoucine
Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine

Biological Activity:

Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM)  and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase.

Technical Data:

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M.Wt: 298.35
Formula: C15H18N6O
Storage: Desiccate at -20°C
Solubility: Soluble to 50 mM in Ethanol
CAS No: [101622-51-9]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Vesely et al (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 224 771. Abraham et al (1995) Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 83 105. Alessi et al (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 245 8.
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    Keywords: Olomoucine, Kinases, Cyclin-dependent Kinase Inhibitor, Tocris Bioscience
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