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Oleylethanolamide
Chemical Name:(9Z)-N-(2-Hydroxyethyl)-9-octadecenamide
Biological Activity:
Lipid mediator and analogue of anandamide (Cat.
No. 1339) that is involved in peripheral regulation of feeding. Does not
activate cannabinoid receptors but is a PPARα agonist (EC50
= 120 nM) in vitro and in vivo; induces satiety through activation of PPARα. Also a
ceramidase inhibitor.
Coroneoset al
(1995) Differential regulation of sphingomyelinase and ceramidase activities by
growth factors and cytokines. J.Biol.Chem. 270 23305. de
Fonsecaet al (2001) An anorexic lipid mediator regulated by
feeding. Nature 414 209. Calignano et al (2001)
Antinociceptive activity of the endogenous fatty acid amide,
palmitylethanolamide. Eur.J.Pharmacol. 419 191.Fuet al (2003)
Oleylethanolamide regulates feeding and body weight through activation of the
nuclear receptor PPAR-α.
Nature 425 90.
Analogue of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Induces activation of RhoA, cdc42 and rac1.
