Ochratoxin A | Signal Transduction | Stimulates SERCA-ATP-dependent Ca2+ Pump Activity

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Cat.No.	Product Name
1291	Ochratoxin A

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Ochratoxin A

Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo- 1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine

Biological Activity:

Mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.

Technical Data:

M.Wt:	403.82
Formula:	C₂₃H₁₉ClNO₆
Storage:	Desiccate at +4°C
Solubility:	Soluble to 50 mM in Ethanol
Purity:	>99%
CAS No:	[303-47-9]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch

References:

Merck Index 12 6836. Dirheimer and Creppy (1991) Mechanism of action of ochratoxin A. IARC Sci.Publ. 115 171. Omar et al (1991) Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation. J.Biochem.Toxicol. 6 203. Chong and Rahimtula (1992) Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro. Biochem.Pharmacol. 44 1401. Gekle et al (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J.Pharmacol.Exp.Ther. 293 837.

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Keywords: Ochratoxin A, Signal Transduction, Stimulates SERCA-ATP-dependent Ca2+ Pump Activity, Tocris Bioscience

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