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Category:
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Transporters Neurotransmitter TransportersCannabinoid Transporters
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Cat.No.
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Product Name
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1446 |
O-2093
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Price and Availability
Click here for full price details of
O-2093
Other Information:
Sold
under licence
from VCU-IPF
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Chemical Name:
N-(bis-3-chloro-4-hydroxybenzyl)-5Z,8Z,11Z,14Z-eicosate
traenamide |
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Biological Activity:
Inhibitor of anandamide uptake (IC50
= 17.3 μM)
with little or no activity at CB1, CB2, TRPV1 and FAAH.
Intravenous administration inhibits limb spasticity in mice with chronic
relapsing experimental allergic encephalomyelitis (CREAE).
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Technical Data:
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M.Wt:
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584.62
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Formula:
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C34H43Cl2NO3
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Storage:
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Desiccate at -20°C
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Solubility:
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Soluble in Ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
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Resources:
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Certificate of Analysis / MSDS:
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References:
Griffin et al (2001) Activity of a
novel anandamide analog suggests a non-CB1, non-VR1 site of action. 2001 Symposium on
the Cannabinoids, International Cannabinoid Research Society. Di
Marzo et al (2002) A structure/activity relationship
study on arvanil, an endocannabinoid and vanilloid hybrid.
J.Pharmacol.Exp.Ther. 300 984. Ligresti et al
(2006) New potent and selective inhibitors of anandamide reuptake with
antispastic activity in a mouse model of multiple sclerosis. Br.J.Pharmacol. 147
83.
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View related products by Pharmacological Action
or by Research Area
Keywords: O-2093, Neurotransmitter Transporters, Inhibitor Of Anandamide Uptake, O2093, Tocris Bioscience
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