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Category: TransportersarrowNeurotransmitter TransportersarrowGABA Transporters
Cat.No. Product Name
0236

(±)-Nipecotic acid  

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(±)-Nipecotic acid
Chemical Name: (±)-3-Piperidine carboxylic acid

Biological Activity:

GABA uptake inhibitor. IC50 values are 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

Technical Data:

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M.Wt: 129.16
Formula: C6H11NO2
Storage: Store at RT
Solubility: Soluble to 100 mM in Water and to 100 mM in 1eq. NaOH
CAS No: [60252-41-7]

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    References:

    Schousboe et al (1979) Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA binding. J.Neurochem. 33 181. Krogsgaard-Larsen et al (1981) GABA agonists, antagonists and uptake inhibitors. Design and therapeutic aspects. J.Med.Chem. 24 1377. Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219.
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    Keywords: (±)-Nipecotic Acid, Neurotransmitter Transporters, GABA Uptake Inhibitor, Nipecotic Acid, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    GABA Receptors
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