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Category: Ion ChannelsarrowCalcium ChannelsarrowVoltage-gated Calcium Channels
Cat.No. Product Name
0600 Nimodipine  
Price and Availability

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Nimodipine
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylic acid 2-methyloxyethyl 1-methylethyl ester

Biological Activity:

L-type Ca2+ channel blocker.

Technical Data:

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M.Wt: 418.45
Formula: C21H26N2O7
Storage: Store at RT
Solubility: Soluble to 100 mM in DMSO and to 10 mM in Ethanol
Purity: >99%
CAS No: [66085-59-4]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
    Product/Material Safety Data Sheet: View current batch

    References:

    Auer et al (1981) Pial arterial vasodilation by intravenous nimodipine in cats. Arzneim.Forsch. 9 1423. Izquierdo (1990) Nimodipine and the recovery of memory. TiPS 11 309. Kappelle et al (1994) Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. Br.J.Pharmacol. 111 887. Batuecas et al (1998) Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. Eur.J.Pharmacol. 350 141.
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    Keywords: Nimodipine, Calcium Channels, Ca2+ Channel Blocker (L-type), Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Mechanisms for Manipulating Intracellular Calcium Buffering
    Download PDF
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..”
    Researcher, University of Aberdeen, UK
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