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Category: EnzymesarrowOxygenases/OxidasesarrowCyclooxygenase
Cat.No. Product Name
2470 Nimesulide
Alternative name(s): Flogovital
Aulin
Price and Availability

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Nimesulide
Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

Biological Activity:

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs.  

Technical Data:

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M.Wt: 308.31
Formula: C13H12N2O5S
Storage: Store at +4°C
Solubility: Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Purity: >99%
CAS No: [51803-78-2]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437. Cullen et al (1998) Selective cyclooxygenase-2 inhibition by nimesulide in man. J.Pharmacol.Exp.Ther. 287 578.
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    Keywords: Nimesulide, Oxygenases / Oxidases, Cyclooxygenase-2 (COX-2) Inhibitor, Flogovital, Aulin, Tocris Bioscience

    Literature in this Area
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    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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