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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT2 Receptorsarrow5-HT2A
Cat.No. Product Name
2777 Nefazodone hydrochloride
Price and Availability

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Nefazodone hydrochloride
Chemical Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride

Biological Activity:

Serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Displays no activity at 5-HT1B and 5-HT1D receptors. Active in models predictive of antidepressant potential.

Technical Data:

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M.Wt: 506.47
Formula: C25H32ClN5O2.HCl
Storage: Desiccate at RT
Solubility: Soluble to 10 mM in 1eq. HCl and to 25 mM in DMSO
Purity: >99%
CAS No: [82752-99-6]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Eison et al (1990) Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol. Bull. 26 311. Davis et al (1997) Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs 53 608. Pullar et al (2000) LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine2A receptor antagonist: a comparison with the antidepressant, nefazodone. Eur.J.Pharmacol. 407 39.
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    Keywords: Nefazodone Hydrochloride, 5-HT Receptors, 5-HT2A Antagonist & 5-HT Uptake Inhibitor. Antidepressant, Tocris Bioscience
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