Naltrindole Hydrochloride | Opioid Receptors | D Selective Non-peptide Antagonist

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7TM Receptors

Opioid Receptors

Delta Receptors

Antagonists

Cat.No.	Product Name
0740	Naltrindole hydrochloride

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Naltrindole hydrochloride

Other Information:

Sold with the permission of the University of Minnesota

Chemical Name: 17-(Cyclopropylmethyl)-6,7-dehydro-4,5a-epoxy-3,14-dihy droxy-6,7-2',3'-indolomorphinan hydrochloride

Biological Activity:

Highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors.

Technical Data:

M.Wt:	450.96
Formula:	C₂₆H₂₆N₂O₃.HCl
Storage:	Store at RT
Solubility:	Soluble to 10 mM in Ethanol and to 25 mM in Water and to 100 mM in DMSO
Purity:	>99%
CAS No:	[111469-81-9]

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References:

Portoghese et al (1990) Design of peptidomimetic δ opioid receptor antagonists using the message-address concept. J.Med.Chem. 33 1714. Ossipov et al (1994) Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCK_B antagonist in the rat. Neurosci. Lett. 181 9. Shippenberg and Heidbreder (1995) The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine. Eur.J.Pharmacol. 280 55.

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Keywords: Naltrindole Hydrochloride, Opioid Receptors, D Selective Non-peptide Antagonist, Tocris Bioscience

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